I use the built-in Font Book application
  1. Open /Applications/Utilities/Activity Monitor
  2. Find the ‘fontd’ process and kill/delete it
  3. Open /Applications/Font Book
  4. Run the utility to Edit > Check for Duplicate Fonts and remove any duplicates found
  5. Run File > Validate Fonts and remove any problem fonts it turns up
I use an anti-virus software
  1. Turn off the anti-virus
  2. Restart the PrintPoint application
  3. If PrintPoint is still running slow then the anti-virus is not causing the problem.
  4. If PrintPoint is running faster then turn your anti-virus back on and add PrintPoint to the exceptions.